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A new study shows a positive link between brain health and a naturally occurring compound in edible mushrooms, ergothioneine (ET). Previous observational studies have shown an inverse relationship between circulating ET levels and the risk for neurodegenerative diseases, often attributed to its antioxidant activity. However, the new study found that it might further support brain health by activating a part of the cell that operates as the “master regulator of endogenous antioxidant response.”